Why does the same exercise exert effects on individuals differently?

Selenoprotein P, a kind of hepatokine hormone secreted from the liver, has been found, through experiments with cultured muscle cells and mice and through clinical studies, to cause pathology named 'exercise resistance,' which prevents health promotion by physical exercise. The present results elucidate one of the reasons why individual responsiveness to exercise differs markedly as well as shed lights on development of therapy for lifestyle diseases due to lack of exercise, obesity and type-2 diabetes.

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Should Trabecular Bone Score Be Used to Assess Bone Quality in Type 2 Diabetes?

The trabecular bone score may provides an acute, albeit indirect, measurement of bone quality in patients with type 2 diabetes.

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Acute Kidney Injury Rate High in Hospitalized Children With Diabetic Ketoacidosis

Of the children who developed acute kidney injury, 34.9% had stage 1, 45.3% had stage 2, and 19.8% had stage 3.

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Scientists discover new class of anti-diabetes compounds that reduce liver glucose production

A team of scientists has identified a new class of compounds that reduce production of glucose in the liver, which is linked to type 2 diabetes, the form of diabetes considered responsible for close to 95 percent of cases in the United States.

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Implementing large-scale teleretinal diabetic retinopathy screening program

Can a large-scale, primary care-based teleretinal diabetic retinopathy screening (TDRS) program reduce wait times for screening and improve the timeliness of care in the Los Angeles County Department of Health Services, the largest publicly operated county safety net health care system in the United States?

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‘Medicinal food’ diet counters onset of type 1 diabetes

Researchers have found — for the first time — that a diet yielding high amounts of the short-chain fatty acids acetate and butyrate provided a beneficial effect on the immune system and protected against type 1 or juvenile diabetes.

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Biomarker found that could help predict the onset of Type 1 diabetes

A significant finding has been made that has the potential to contribute to the identification of biological markers that predict the development of Type 1 diabetes, a chronic autoimmune disease.

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Diabetes Risk in Elderly Women Increased by Statin Use

Although statins reduce CV events, they may increase the risk of new-onset diabetes in older women.

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Which drugs effectively treat diabetic nerve pain?

Certain antidepressants and anti-seizure drugs are among medications that effectively treat diabetic nerve pain, a federal health agency has found.

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Sniffing out a new strategy against Alzheimer’s disease

Neurologists are conducting an 18-month clinical trial testing a type of insulin delivered in a nasal spray – which is used to treat diabetes in some patients – in the Study of Nasal Insulin to Fight Forgetfulness (SNIFF).

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Survivors of childhood brain tumors have increased body fat

New research findings suggest that one of the most important risk factors for heart disease and type 2 diabetes, which is excess total and central fat in the body, is present relatively early in survivors of childhood brain tumors. This may program their future risk of these diseases and impact their outcomes.

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Diabetes damages small coronary blood vessels and thus increases the risk of heart attacks

Diabetics have a significantly higher risk of suffering a heart attack. A research team has now identified one of the causes: Diabetes is associated with the loss of small blood vessels around the heart. This in turn affects the entire cardiac muscle. A genetic therapy that promotes the growth of blood vessels may offer a remedy.

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Higher Complications, Comorbidities in Youth With Type 2 Versus Type 1 Diabetes

The prevalence of complications associated with type 1 and type 2 diabetes diagnosed during childhood and adolescence was compared in a multicenter, observational study.

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Study suggests new way to prevent vision loss in diabetics, premature babies

A new molecule that induces the formation of abnormal blood vessels in the eyes of diabetic mice has been discovered by researchers. Their study suggests that inhibiting this molecule may prevent similarly aberrant blood vessels from damaging the vision of not only diabetics, but also premature infants.

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Diabetes researchers discover way to expand potent regulatory cells

For parents, storing their newborn baby's umbilical cord blood is a way to preserve potentially lifesaving cells. Now, a group of researchers has found a way to expand and preserve certain cord-blood cells as a potential treatment for type 1 diabetes.

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Insulin resistance may lead to faster cognitive decline

Insulin resistance, caused in part by obesity and physical inactivity, is also linked to a more rapid decline in cognitive performance, new research suggests.

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Angiography May Mitigate Poor CV Outcomes In Diabetes

Patients with diabetes had more CV risk factors and higher rates of noninvasive testing positivity.

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How to Avoid GI Distress When Running

Gut Pain Runner H

You’ve put in the long runs. You’ve shown up for sunrise speed work. You even turned in early a few nights to make sure you got enough shut-eye.

Today is my day, you think as you approach the starting line.

Not so fast, rumbles your stomach, the archenemy of so many runners.

Take comfort in knowing that you’re not alone in your poop plight. A recently published study in the Human Kinetics Journal found that, during a 30-day period, male runners reported at least one symptom of GI distress on 84 percent of runs. Women, meanwhile, faced GI issues 78.3 percent of the time. Why? Because running, unlike cycling or swimming, includes a whole lot of jostling, says Patrick Wilson, an assistant professor of human motion sciences at Old Dominion University, in Virginia, and the lead author of the paper. “In addition, gut blood flow is compromised during high-intensity and prolonged exercise, which can ultimately cause dysfunction and damage to the GI tract.” The gut-wrenching trio of vigoro..

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The 5-Minute Warm-Up for Any Sport

Pre Workout Stretch H

We can’t blame you for wanting to skip the fitness foreplay and go straight into your sport, especially when time is limited. But the hurried approach does more than just slow your first few miles or stiffen your reps. When you drop the hammer before your body is ready, at best you’re limiting your performance potential; at worst, you’re putting yourself at much greater risk for injury, according to researchers at the University of Alabama.

Many people skip the warm-up because they assume an effective routine must also be a long one. But science tells us that’s just not the case. The right set of moves can prep and prime your body in just five minutes, says Doug Kechijian, co-founder of Resilient Performance Physical Therapy, in New York City. “An ideal warm-up elevates your heart rate and body temperature, allows you to move better during your activity, and gets your system ready to fire,” he explains.

Kechijian has worked with every type of athlete in the book, from Special Forces ..

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Trail Runners Join the Fight for Public Lands

Run Wild Bowman H

Last week the Trump administration presented a budget proposal for 2018 that featured significant cutbacks to a number of government agencies. Among a host of other reductions, one proposed cut would give the Environmental Protection Agency its smallest operating budget since its inception in 1970. Against this backdrop of shifting national priorities, a new grassroots initiative called Run Wild is hoping to engage the trail-running community in the fight to protect public lands.

Run Wild's website went live earlier this month, and the founders are still figuring out what the specifics of the fledgling project’s activism will look like. At present, the emphasis is on getting the word out, growing its network, and advocating for increased appreciation of the roughly 640 million acres of national heritage that all Americans collectively own. The organization, which has ten cofounders, has partnered with the Wilderness Society, a nonprofit that has been on the front lines of the con..

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Cellular jetlag seems to favor the development of diabetes

Like almost all light-sensitive living beings, human beings follow biological rhythms set on a period of about 24 hours. The circadian clock therefore describes the internal system that allows us to anticipate the changes of day and night by regulating nearly all the aspects of our physiology and behavior. At a time when our biological rhythms are increasingly undermined – whether by night work, jetlag, or societal habits, – scientists begin to unveil the impact such circadian misalignments may have in the explosion of metabolic diseases.

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